One of the largest snakes in the world, this African rock python consumes an antelope, whole.
Here you can get a first-hand glance as to how a large, limbless reptile can consume an equally large prey item--an adult springbok.
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African rock pythons, like all macrostomata (big mouthed) snakes, take advantage of their loosely connected jaw structure by consuming immense, unthinkably large prey completely intact--yes, whole.
They're able to perform this feat of anatomical wonder via the loosely connected tendons that join both the lower and upper regions of the mandible; the "limit of expanse" seems to hit a wall at over five times the size of the given snake's skull. This video very kindly gives us a look at this process with an internal camera in the snake's mouth.
After consuming such a meal, a full-bellied large python might not need to feed for over twelve months.