You need to be ready for anything in a combat situation. That includes being ready to face off against multiple targets. Watch the video below to get a few training tips to get you started.
The key to engaging multiple targets is speed. You always want to account for every round you fire.
When your life is on the line, however sending lead into a threats center of mass is your best chance of living. As stated in the video throwing lead down range even when not in a perfect scenario is the right choice.
Once you get this concept down the only thing I would add is to start moving your feet. In a real life scenario those targets are going to move and shoot back. Move, shoot, and live.